Crystalline Nanosuspensions as Potential Toxicology and Clinical Oral Formulations for BCS II/IV Compounds

Conventional Concept of Formulations of Nanosuspensions

Poorly water soluble molecules are typically formulated for improving their dissolution rate and storage stability by increasing active drug surface area that come in the contact with the dissolution medium [4]. Most important characteristics of nanosuspensions are their exhibited particle size; polydispersity index, drug saturation solubility, physical stability, dissolution rate and bioavaila...

Preparation and Characterisation of Nevirapine Oral Nanosuspensions

The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine can lead to decreased and variable oral bioavailability. Nanosuspension can o...

Clinical studies with oral lipid based formulations of poorly soluble compounds

This work is an attempt to give an overview of the clinical data available on lipid based formulations. Lipid and surfactant based formulations are recognized as a feasible approach to improve bioavailability of poorly soluble compounds. However not many clinical studies have been published so far. Several drug products intended for oral administration have been marketed utilizing lipid and sur...

phenolic compounds as potential antioxidant

Evaluation of pre-clinical safety and toxicology of Althaea officinalis extracts as naturopathic medicine for common carp (Cyprinus carpio)

The current study was done to investigate the preclinical safety and toxicology of Althaea officinalis extract as naturopathic medicine in common carp (Cyprinus carpio). Specimens were treated with 0 (control), 2.5, 5 and 10 g of marshmallow extract for 45 days. Plasma biochemical parameters were measured after 15 and 45 days. Total protein, albumin and globulin levels (p < /em>>0.05). During t...